Internal Medicine: Open Access
Open Access
ISSN: 2165-8048
+44 1300 500008
ISSN: 2165-8048
+44 1300 500008
Guangdong Provincial Key Laboratory of Development and Education for Special Needs Children, Zhanjiang, Guangdong, China
Research Article
The Regulatory Role of the SIRT1/Foxo1 Pathway in the Prevention of Insulin Resistance in Skeletal Muscle by Aerobic Exercise in Mice
Author(s): Haitao Wang and Wenqian Yang
Silent Information Regulator Proteins (SIRT) plays key roles in glucose and lipid metabolism and homeostasis. The SIRT1 inhibitor was used to investigate the mechanism of the SIRT1/FoxO1 (Forkhead box O1) pathway in mice and its function in the prevention of insulin resistance in skeletal muscle. Forty male mice were randomly divided into a control group and three experimental groups (NH: High-fat diet, HE: High-fat diet plus exercise, and HES: High-fat diet plus exercise and SIRT1 inhibitor). After 14 weeks, the fat weight, blood glucose level, and HOMA-IR score in HES were significantly increased compared to those in HE (P<0.01). The same parameters were significantly decreased in HE compared to those in the NH group (P<0.01). Mitochondrial 8-OHdG (8-hydroxy-2 deoxyguanosine) level of the HES group was significantly higher than that of the HE group (P<0.01). Compared with N.. View More»