ISSN: 2572-0775
Department of Pediatric, Edward via College of Osteopathic Medicine (VCOM)-Carolinas, Spartanburg, South Carolina 29303, United States
Case Report
Atypical Antipsychotic Toxidrome: A Case Report and a Proposed New Toxicity Syndrome
Author(s): Hanna S. Sahha*, Maichoua S. Lor and Lauren Bailey
Quetiapine is an atypical antipsychotic medication approved by the U.S. Food and Drug Administration to treat
psychosis and mood disorders. Side effects of quetiapine when used at therapeutic levels include sedation, weight
gain, and orthostatic hypotension. Quetiapine toxicity in overdose or misuse presents with autonomic instability,
miosis, hypotension, extrapyramidal symptoms, and QTc interval prolongation. We present a unique case of an
unsuspected quetiapine overdose in a 17-year-old male with comorbid untreated epilepsy. The patient presented with
acute dystonia, central nervous system depression, and miosis. The patient required endotracheal intubation and
mechanical ventilation and was treated with supportive care. He subsequently developed neuroleptic malignant
syndrome and aspiration pneumonia. The patient recovered completely without residual symptoms... View More»
DOI:
10.35248/2572-0775.22.7.223