Journal of Molecular Imaging & Dynamics
Open Access
ISSN: 2155-9937
ISSN: 2155-9937
National Institute of Technology, Thiruchirappalli, India
Case Report
Changing Amino Acid Infusion Rate Did Not Alter Renal Function, the Biodistribution and Subsequent Outcome of Lutathera Therapy: Report of an Experience Resulted by an Accidental Broken Lutathera Vial
Author(s): Jitesh Dhingra*, Harry Schroeder, Saima Muzahir and Raghuveer Halkar
The use of peptide-receptor radionuclide therapy (PRRT) with Lutathera for metastatic neuroendocrine tumors (NETs) has demonstrated an increased progression free survival. [1] High concentration of Lutathera in the kidneys requires amino acid infusion pre and post administration of Lutathera to protect the kidneys from radiation effects. The ACR–ACNM–ASTRO– SNMMI practice guidelines and the IAEA, EANM, and SNMMI guidelines describe that the amino acid infusion should be started 30 minutes prior to 177-Lu Dotatate therapy and continued for 3 hours post 177 Lu-Dotatate. The rate of amino acid infusion should be 250ml/hour. [2] The literature on the effect of different infusion rates of amino acids on the biodistribution of Lutathera and subsequent outcome of therapy is limited. Here we report our experience of the effect of a slower infusion rate of amino acids on the .. View More»