Journal of Infectious Diseases & Preventive Medicine
Open Access

Department of Microbiology, Immunology & Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40506, USA

Biography

Heinz Kohler was born in Berlin, Germany, where he grew up before and during World War II. By the war's end, he found himself in rural East Germany and spent years watching the Nazi tyranny give way to a Communist one. He made it to West Berlin before the Wall went up and came to the United States in the late 1950s. Since 1961, he was associated with Amherst College, Massachusetts, where he became the Willard Long Thorp Professor of Economics, taught Economics as well as Statistics, and published numerous textbooks on both subjects.

Publications

• Research Article   
  Towards an HIV Vaccine Based on Immune Network Theory II
  Author(s): Geoffrey W. Hoffmann*, Teri Otto, Michael Grant, Sybille Muller* and Heinz Kohler
  
  We have designed immunization protocols based on the co-section model to induce a broadening antigen antibody response against HIV1. As antigen were various antigen-antibody complexes used, including the monoclonal antibody 1F7 that is expressed on anti-HIV1 antibodies with different antigen specificities. Rabbits were used to test this concept using. Antibodies that neutralized HIV-1 of the same strain as that of the gp120 used were detected, but they did not include broadly neutralizing antibodies (BnAbs). Immunization with gp120 in adjuvant induced antibodies binding to gp120, gp41, Nef and p24, a finding predicted by the immune network theory. Furthermore a complex of 1F7 and B12 induced antibodies against gp120 and gp41, demonstrating an antigen broadening response towards achieving the goal of inducing BnAbs through immunization... View More»
  DOI: 10.35248/2329-8731.19.7.190

  Abstract HTML PDF