Journal of Leukemia
Open Access

Department of Hematological Pathology, Stellenbosch University, Stellenbosch, South Africa

Biography

Dr. Helena Cornelissen is the Assistant Professor in the Department of Hematological Pathology, Stellenbosch University, Stellenbosch, South Africa. Currently, Dr. Helena Cornelissen is the author/reviewer in several international journals. He published 7 articles in journals and the articles are informative and got good citations.

Publications

• Case Report   
  T-Cell/Myeloid Mixed-Phenotype Acute Leukemia with KMT2A Rearrangement
  Author(s): Ibtisam Abdullah, Monalisa Ntobongwana, Leilah Schoonraad, Helena Cornelissen and Zivanai Cuthbert Chapanduka*
  
  Mixed Phenotype Acute Leukemia (MPAL) is a rare leukemia subtype arising from hematopoietic pluripotent stem cells. The hallmark of the disease is co-expression of myeloid antigens and B- or T-lymphoid antigens. We discuss an 11-year-old female, who presented with gum hypertrophy, lymphadenopathy and anemia with 84% blasts on peripheral blood examination. Immunophenotyping revealed two blast populations co-expressing markers of both T-cell and myeloid lineages with monocytic differentiation. Cytogenetics showed t (6;11). The diagnosis of T-cell/myeloid MPAL with KMT2A rearrangement was made. Two rare features noted were, the two distinct myeloid and monocytic blast sub-populations and T-cell/myeloid marker co-expression with KMT2A-rearrangement. The KMT2A rearrangement has been associated with B-cell/myeloid mixed phenotypic leukemia however association wit.. View More»
  

  Abstract PDF