Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
+44 1300 500008
ISSN: 2167-0412
+44 1300 500008
Department of Functional Genomics and Cancer, Institute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch, France, France
Research Article
Induction of Tumor-Selective Cytotoxicity by Myrtus communis L. Extract and its Bioactive Metabolite 1, 8-cineole
Author(s): Yasenya Kasikci*, Ayfer Pazarbasi, Seray Karacay, Durmus Kaya A, Gülay Duran G, Akinchan Kumar, Bertan Yılmaz M and Hinrich Gronemeyer
Breast cancer is the most common type of cancer in women. Despite current treatments, new treatments should be investigated. The antioxidant and apoptotic activities of plant metabolites have attracted increasing interest in the molecular pharmacology. Here, we investigated the anti-proliferative and apoptotic potential of Myrtus communis L. extracts, used in traditional medicine. To monitor cancer-selective activities, the extract and its most prominent components were assayed in parallel with human MCF7 breast cancer and normal MCF10A mammary epithelial cells. Indeed, we observed a potential therapeutic window of concentrations with significantly higher toxicity for the tumor cells. GC-MS confirmed the presence of α-pinene, 1,8-cineole, linalool as major components. Analyzing these pure terpenoids revealed exclusive toxicity of 1,8-cineole for MCF7 cells, whereas no t.. View More»
DOI:
10.35248/2167-0412.21.10.371