Rheumatology: Current Research
Open Access

Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, Japan

Biography

Dr. Hirokazu Sugiyama is a is board-certified Professor by the Aichi Medical University, Nagakute, Japan, renowned researcher and author in the specialty of Department of Nephrology and Rheumatology.

Publications

• Research Article   
  A Case of Eosinophilic Granulomatosis with Polyangiitis with Severe Peripheral Neuropathy Refractory to Standard Treatment Successfully Treated by Mepolizumab
  Author(s): Seika Terashima, Makoto Yamaguchi, Takayuki Katsuno, Hirokazu Sugiyama, Shiho Iwagaitsu, Hironobu Nobata, Hiroshi Kinashi, Shogo Banno and Yasuhiko Ito*
  
  The clinical benefits of administering mepolizumab to patients with Eosinophilic Granulomatosis with Polyangiitis (EGPA) to prolong the remission period have recently been reported. However, the timing of initiating mepolizumab and the clinical characteristics that are best indicators for mepolizumab treatment have not yet been identified. Herein, we report the case of a 57-year-old male Japanese patient with Anti-Neutrophil Cytoplasmic Antibody (ANCA)-negative EGPA who manifested severe peripheral neuropathy refractory to standard therapy. The patient was administered with a high-dose steroid, intravenous cyclophosphamide, intravenous immune globulin, and finally mepolizumab, which resulted in the clinical improvement of nervous symptoms without any adverse effects. Clinicopathologically, ANCA-negative peripheral neuropathy might be caused by eosinophil-associated.. View More»
  DOI: 10.35248/2161-1149.21.11.272

  Abstract HTML PDF