Journal of Proteomics & Bioinformatics
Open Access

Iranian Research Organization for Science and Technology (IROST), Department of Chemical Technologie, Food Science and Technology Group, Mojtama Asre Enghelab Building, Shahid Ehsanirad Street, 33535111, Tehran, Iran

Publications

• Research Article   
  A Bioinformatic Approach for COVID-19 Spike Glycoprotein Deactivation by Chemical Modification of Asparagine and Lysine Residues via Vitamin B6 and Vitamin C
  Author(s): Homa Torabizadeh*
  
  To invade human cells, COVID-19 uses its spike glycoprotein as the major surface protein. This glycoprotein can be inactivated through chemical modification of surface accessible asparagine and lysine residues by vitamin B6 (pyridoxal-5'-phosphate, PLP) and vitamin C (ascorbic acid). This reversible reaction leading to the formation of a Schiff base (aldimine), and consequent reduction by ascorbate lead to form a stable phosphopyridoxyl-lysyl or asparagyl covalent bonds. For this purpose, at first, the spike glycoprotein sequences in similar proteins with 100% identity was specified by using of UniProtKB that is located at the ExPASy server. All of these proteins have a 1,255 length and 139,125 Mass (Da) respectively. Then, GetArea software was used for accessible surface area determination of each sequence by employing of PDB files that is reserved at PDB website. The res.. View More»
  DOI: 10.35248/0974-276X.22.15.591

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