Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Gastroenterology, Changzhou Jintan First People's Hospital Affiliated to Jiangsu University, Jintan, China
Research Article
MicroRNA-365 Targets Nrf2 to Enhance Erastin-Induced Ferroptosis in Gastric Cancer Cells
Author(s): Hui Cao, Ming Ding and Kai Zhao*
Gastric cancer is globally recognized as a significant malignancy and a leading cause of cancer mortality. Ferroptosis,
as a new form of regulated cell death, is attracting increasing attention in worldwide. As knows that, MicroRNA-365
(MiR-365) has been implicated in the carcinogenesis of gastric cancer, but its role in ferroptosis remains elusive. The
aim of our study is to clarify how miR-365 regulate ferroptosis in gastric cancer cells.
Erastin is regarded as a ferroptosis inducer, our study found that with over-expression of miR-365 mimics also could
enhance erastin-induced ferroptosis in gastric cancer cells. Additionally, miR-365 overexpression further upregulated
the levels of MDA, Fe2+ and ROS in gastric cancer cells exposed to erastin, while antioxidant GSH levels were further
downregulated, suggestive of enhanced lipid oxidation in gastr.. View More»
DOI:
10.35248/2736-6588.24.7.284