Immunotherapy: Open Access
Open Access

Department of Stomatology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and T, China

Publications

• Research Article   
  ATG5 Promotes Head and Neck Squamous Cell Carcinoma by Regulating Translation and Cell Cycle
  Author(s): Haidong Fan*, Junquan Weng, Huijuan Liu, Hui Zhang and Su Tang
  
  Background: Head and Neck Squamous Cell Carcinoma (HNSCC) is the most prevalent malignant tumor of the maxillofacial area. ARGs (Autophagy-Related Genes) are involved in the cell cycle and translation, which will fuel carcinogenesis. Material and methods: TCGA data for ARGs in HNSCC were analyzed. The functional role of the ATG5 in HNSCC was investigated through ATG5 knockdown cell lines. Results: According to the TCGA data, ATG5 was shown to be an adverse prognostic marker. Regardless of tumor stage, grade, or clinical characteristics, HNSCC patients with high ATG5 expression had a poorer survival rate. ATG5 knockdown suppressed the malignant features of HNSCC cell lines. The mechanism study demonstrated ATG5 knockdown could prevent the malignant phenotype .. View More»
  DOI: 10.35248/2471-9552.22.8.200

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