Immunotherapy: Open Access
Open Access

Division of Chemistry and Biochemistry, Kangwon National University, Chuncheon, 24341, Korea

Biography

Professor
Sungkyunkwan University, South Korea Prof. Hyun Suk Jung completed his B.S. (1997), M.S. (1999), and Ph.D. (2004) in Seoul National University, Korea. He is currently a professor at School of Advanced Materials Science and Engineering, Sungkyunkwan University, Korea. He was an associate professor at Sungkyunkwan University, Korea (2011-2017), an assistant professor at Kookmin University, Korea (2006-2011), a director’s funded postdoctoral fellow at Los Alamos National Laboratory, USA (2005-2006), a post-doc at Research Institute of Advanced Materials, Seoul National University, Korea (2004-2005)

Publications

• Research Article   
  Neuroprotective Effect of Glial Cell-Derived Exosomes on Neurons
  Author(s): Sujin Hyung, Ju Young Kim, Chan Jong Yu, Hyun Suk Jung and Jong Wook Hong*
  
  Recent research has revealed that exosomes affect several aspects of organism physiology and development, as well as disease processes, through intracellular communication. However, the biological roles of exosomes in exosomesecreting cells have remained largely unexplored. In this study, we demonstrate that Schwann cell (SC)-derived exosomes (EXOSC) promote cell survival among motor neurons (MNs), with MN viability exceeding 80% at days in vitro (DIV) 14. Prevention of MN cell death by EXOSC was achieved by blocking the caspase-3 cell death pathway, which was confirmed by comparing the number of activated-caspase3+ cells according to the presence versus absence of EXOSC. The attenuation of exosome secretion from SCs by treatment with GW4869 resulted in increased MN cell death, regardless of SC viability. Together, these findings enhance our understand.. View More»
  DOI: 10.35248/2471-9552.19.5.156

  Abstract HTML PDF