Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
Department of Endocrinology, Diabetology and Metabolic Diseases, University Hospital of Clermont Auvergne, Clermont–Ferrand, F–63000, France
Review Article
Effect of Levothyroxine Treatment on Heart Rate Variability in Hypothyroidism: Systematic Review and Meta-Analysis
Author(s): Valentin Brusseau*, Igor Tauveron, Reza Bagheri, Ukadike Chris Ugbolue, Valentin Magnon, Valentin Navel, Jean-Baptiste Bouillon and Frederic Dutheil
Introduction: We performed a systematic review and meta-analysis of the effect of levothyroxine treatment on Heart Rate Variability (HRV) in hypothyroidism. Indeed, abnormalities of HRV exist in hypothyroidism, but their reversibility after treatment remains contradictory.
Methods: We searched for articles related to HRV parameters in treated and untreated hypothyroidism in different databases (pubmed, cochrane, embase, and google scholar) until November 15, 2022. We performed a meta-analysis for each HRV parameter, stratified according to the degree of hypothyroidism: RR intervals (or Normal to Normal intervals-NN), SDNN (Standard Deviation of RR intervals), RMSSD (square root of the mean difference of successive RR intervals), pNN50 (percentage of RR interval with more than 50 ms of variation), Total Power (TP), LFnu (Low-Frequency normali.. View More»
DOI:
10.35248/2161-1017.23.12.378