Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Department of Biochemistry, Joseph Saawuan Tarka University, Makurdi, Nigeria
Research Article
The Effects of Active Fractions and Ethanolic Fruit Extract of Raphia hookeri on Aluminium Chloride-Induced Toxicity in Male Wistar Rats
Author(s): John Akighir*, Eje Ojochenemi Yakubu, Chinedu Imo, Ayu Agbecha, Ikani Richard Odama and Msughter Martin Ganyam
Aluminium (AL) is the third most abundant element in the earth’s crust and constitutes about 8% of the
total mineral components. The availability of AL has recently drawn more attention to its bio-toxicity. Hence the
effects of aluminium chloride (Alcl3) toxicity on haematological profile administered active fractions and
ethanolic fruits extract of Raphia hookeri in male wistar rats were investigated.
Methodology: A total of 110 healthy male wistar rats weighing 180-200 g were grouped into 11 groups of 10
rats each. Group 1: Normal feed and water (normal control); Group 2: Alcl3; Group 3: 200 mg/kg b.wt. of
vitamin C; Group 4 and 5: N-hexane fraction at 10 and 20 mg/kg b. w; Group 6 and 7: Ethyl acetate fraction at 10
and 20 mg/kg b. w; Group 8 and 9: Aqueous fractions at 10 and 20 mg/kg b. w; Group10 and.. View More»
DOI:
10.35248/2161-0495.23.13.551