Journal of Developing Drugs
Open Access

Department of Pharmacology, Nnamdi Azikiwe University, Nigeria, Awka, Anambra State, Nigeria

Biography

Mbagwu Ikechukwu Sonne works at Nnamdi Azikiwe University, Awka | Unizik · Department of Pharmacology and Toxicology. His publications include Newboulasides A and B, two new caffeic acid glycosides from Newbouldia laevis with α-amylase inhibitory activity, Newbouldia laevis improved glucose and fat homeostasis in a TYPE-2 diabesity mice model, Antidiarrheal property of Napoleona imperialis may be due to Procyanidins and Ellagic acid derivatives and etc.

Publications

• Research Article   
  Low-Dose 17?-Estradiol Supplemented with Andrographis Paniculata Improved Glucose and Lipid Homeostasis in a Type-2 Diabesity Mice Model
  Author(s): Ikechukwu Sonne Mbagwu, Obiora Celestine Ugwu, Uchechukwu Harrison Orji, Raymond Ogbonna Offiah and Daniel lotanna Ajaghaku*
  
  Estrogens play an important role in metabolic homeostasis. However, its risk of oncogenecity and cardiovascular adverse effects underscores its therapeutic benefits. This study investigated the metabolic effect of low dose estrogen supplemented with Andrographis paniculata on type-2 diabesity mice model. The experimental animals maintained on high fat diet were induced diabetes with streptozotocin (100 mg/kg) after intraperitoneal injection of 50 mg/kg nicotinamide. Low dose estrogen (0.02 mg/kg) was administered alone as well as in combination with 50, 150 and 500 mg/kg of the ethanol extract of A. paniculata. These doses of the extract, vehicle (5 ml/kg distilled water) and two reference standards pioglitazone (30 mg/kg) and metformine (100 mg/kg) were used as controls. Oral glucose tolerance test was used to determine the effect of treatment on pancreatic β-cell function and i.. View More»
  DOI: 10.35248/2329-6631.21.10.204

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