Journal of Antivirals & Antiretrovirals
Open Access

Department of Medicine, Kuwait University, Kuwait City, Kuwait

Biography

Iqbal Siddique works at Department of Medicine, Kuwait University, Kuwait City, Kuwait. His area of research interests includes Infectious diseases, Virology, Medicine. He /she has authored of many research articles/books in the relevant areas.

Publications

• Research Article   
  Relevance of T helper Type 1, 2 and 17 Cytokine Profiles to the Outcome of Therapy in Hepatitis C Patients
  Author(s): Sahar Essa*, Iqbal Siddique, Widad Al-Nakib and Raj Raghupathy
  
  Background: This study aimed to investigate the relationship of T helper type (Th)1/Th2/Th17 type cytokines produced by chronically hepatitis C virus (HCV)-infected patients in response to pegylated interferon-α plus ribavirin (Peg-IFN/RBV) therapy. These finding will help us to identify the type of cytokines which participate in restoring functional antiviral T cell responses resulting in improved viral clearance. Methods and results: Sixty genotype-4 HCV-infected patients received Peg-IFN/RBV therapy for 12 weeks. Levels of Th1 cytokines (IL-2, IL-8, IL-12, TNFα, IFNγ), Th2 cytokines (IL-4, IL-6, IL-10) and Th17 cytokines (IL-17A, IL-17F) were estimated by ELISA. In post-treatment samples, mean levels of Th1 cytokines IL-12 and IFNγ were significantly higher in patients with an early virologic response (EVR) when co.. View More»
  DOI: 10.35248/1948-5964.20.12.193

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