International Journal of Physical Medicine & Rehabilitation
Open Access

Department of Physical Medicine, Jerusalem College of Technology, Jerusalem, Israel

Publications

• Review Article   
  Patience Pays: Game Theoretic Model for the Developmental Competition at the Motor-Muscle System
  Author(s): Irit Nowik*
  
  We offer a new game theoretic approach to analyze the developmental competition that arises between neurons innervating a common muscle. The size principle-stating that neurons with successively higher activation-thresholds innervate successively larger portions of muscle-is thought to result from this competition, but it has not been known how, mainly because the existing experimental data on this issue seems contradictory. We define a multi-stage game in which neurons "compete'' to singly innervate a maximal number of muscle-fibers. At each stage of the game, the competition at a single muscle-fiber is resolved. We show that neurons with successively higher activation-thresholds tend to win in later stages of the game and prove that because resource is limited and is needed both for competing and for maintenance of the connections won, then in order to win more competit.. View More»
  DOI: 10.35248/2329-9096.23.11.680

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