Isabelle De Waziers

Paris Descartes University, France

Biography

Isabelle de Waziers completed her Masters Degree in Nutrition from university Paris VI, France. She completed her PhD in Physiology of Nutrition from University Paris VI, France in 1981. She also did Ph.D in Molecular Pharmacology, Experimental Pharmacology and Metabolism in 1994. Her research works focuse on the study of the function, expression and regulation of enzymes involved in the metabolism of xenobiotics. She has been the active member of Administration Council of Faculty of Medicine in Paris Descartes University, member of the French Society of Biologists and Molecular Biologists.

Publications

Short Communication
Translational Medicine 2015: Usage of engineered mesenchymal stem cells in contradiction of cancers - Isabelle De Waziers - Paris Descartes University
Author(s): Isabelle De Waziers

Gene-Directed Enzyme Pro-Drug Therapy (GDEPT) consists in expression of a suicide gene in tumor cells allowing in place conversion of the pro-drug into cytotoxic metabolites. During a previous work, we demonstrated that the mixture of a mutant CYP2B6 with NADPH Cytochrome P450 reductase (CYP2B6TM-RED), as a suicide gene, and Cyclophosphamide (CPA) might constitute a strong treatment for solid tumors (Touati et al, Curr Gene Ther, 2014). The efficiency of this mix was mainly due to i) an optimized suicide gene ready to metabolize efficiently CPA ii) an efficient bystander effect, iii) the event of an antitumor immune reaction. Major impairments were the directing of the suicide gene exactly to the tumor cells and its low appearance into tumor cells. Indeed, MSCs possess an unprecedented ability to home into tumors due to the inflammatory mediators which are found at the location of a t.. View More»
DOI: 10.35248/2161-1025.20.10.216

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Translational MedicineOpen Access