Journal of Alcoholism & Drug Dependence
Open Access
ISSN: 2329-6488
ISSN: 2329-6488
Department of Neurology, Amygdala Neurosciences Inc, 509 Hale St, Palo Alto CA, 94301, USA
He is affiliated to Amygdala Neurosciences. He is a recipient of many awards and grants for his valuable contributions and discoveries in the major areas of subject research. His international experience includes various programs, contributions, and participation in different countries for diverse fields of study. His research interests reflect in his wide range of publications in various national and international journals.
Research Article
Aldehyde Dehydrogenase 2 Anti-Sense in the Ventral Tegmental Area Reduces Alcohol Drinking
Author(s): Ivan Diamond*, Peidong Fan, Maria P Arolfo and Lina Yao
Background: We have reported that aldehyde dehydrogenase 2 (ALDH2) inhibitors suppress alcohol seeking and drinking in rats even in the absence of alcohol and acetaldehyde. These behavioural changes suggest that ALDH2 in brain could be a target for ANS-6637 inhibition to suppress alcohol seeking and drinking. Here we ask whether ALDH2-RNA anti-sense administered directly into the Ventral Tegmental Area (VTA) also reduces alcohol drinking.
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DOI:
10.35248/2329-6488.19.7.327