Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Department of Physics and Astronomy, Rutgers University, Piscataway, New Jersey, USA
Review
How Life Works: Darwinian Evolution of Proteins
Author(s): J C Phillips*
Here we discuss the development of protein scaling theory, starting from backgrounds in mathematics and statistical mechanics and leading to biomedical applications. Evolution has organized each protein family in different ways, but scaling theory is both simple and effective in providing readily transferable dynamical insights, which are complementary for many proteins represented in the 60 thousand static structures contained in the online Protein Data Base (PDB). Scaling theory is a simplifying magic wand that enables one to search the hundreds of millions of protein articles in the Web of Science and identify those proteins that present new cost-effective methods for early detection and/or treatment of disease through individual protein sequences (personalized medicine). It complements and extends the most popular methods for studying protein evolution, based on amino acid sequenc.. View More»
DOI:
10.35248/0974-276X.24.17.664