Journal of Depression and Anxiety
Open Access

Department of Cardiology and Conservative Intensive Care, Hospital Herford, Herford, Germany

Publications

• Research   
  Acute Anxiolytic Effects of Sacubitril/Valsartan in Patients with Heart Failure
  Author(s): Michael Kellner*, Alexander Yassouridis, Dominik Górski, Saddoff Waheed, Jan Kähler and Klaus Wiedemann
  
  Objective: Anxiety is a frequent symptom in Heart Failure with Reduced Ejection Fraction (HFrEF). By inhibition of the endopeptidase neprilysin, Sacubitril/Valsartan (S/V) blocks degradation of Atrial Natriuretic Peptide (ANP), which has anxiolytic-like effects in man. In patients suffering from HFrEF we presumed an acute anxiolytic action of S/V and its mediation via ANP. Methods: 56 patients with decompensated HFrEF were treated with S/V (24 mg/26 mg b.i.d.) or Treatment As Usual (TAU) without S/V in an open, non-randomized observational pragmatic controlled trial. At days 0 and 7, anxiety was assessed using the Hospital Anxiety and Depression Scale (HADS) and plasma levels of ANP and heart failure biomarker N-Terminal pro B-type Natriuretic Peptide (NT-proBNP) were measured. Results: 35 pa.. View More»
  DOI: 10.35248/2167-1044.23.12.499

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