Journal of Hematology & Thromboembolic Diseases
Open Access

Department of Research and Development, Greffex Inc, Colorado, USA

Publications

• Mini Review   
  Veto-Engineering Immune Tolerance
  Author(s): Janae W Cull, Yan Qi and Uwe D Staerz*
  
  The old veto effect may be moving from its status as an obscure immune inhibitory phenomenon to an important role on specific immune suppression. In today's clinical practice, broad suppression of the immune system is employed to avoid transplant rejection and mitigate auto-aggressive immune responses. Though highly effective, this approach impairs immune protection against infectious challenges. Therapeutic approaches are being sought that specifically inhibit sections of the immune system without affecting beneficial immune functions. One such tactic entails the classical veto-effect that employs donor-derived CD8+ T cells to inhibit cellular immune responses. Indeed, this kind of veto has already found applications as the underpinning of a more broadly applicable CAR-T cell therapy and of a more spec0069fic immune suppression for haploidentical Hematopoietic Stem Cell (HSC) tra.. View More»
  DOI: 10.35248/2329-8790.24.12.609

  Abstract HTML PDF