Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, United States
Research Article
Relationship between Preserved Ellipsoid Zone Area and Choroidal Vascularity Index in Autosomal Dominant Retinitis Pigmentosa
Author(s): Aditya Verma, Swetha Velaga, Muneeswar Gupta Nittala, Kirstie Baker, Xiwen Huang, Jay Chhablani and SriniVas R. Sadda*
Background: Retinitis Pigmentosa (RP) is characterized by changes in the outer retina as well as the choroid. In this study,
we sought to further elucidate the longitudinal relationship between the preserved Ellipsoid Zone (EZ) area and choroidal
parameters, in particular the Choroidal Vascularity Index (CVI).
Patients and methods: Spectral Domain OCT (SD-OCT) volume scans of 48 eyes of 24 subjects with autosomal dominant RP
(ADRP) were collected retrospectively at baseline and month 12. Spectralis Heidelberg Retinal Angiogram (HRA+OCT) scans
(20*20 degrees;512*97;ART=5) were acquired at both visits. A previously described and validated Doheny Image Reading
Center (DIRC) OCT grading software (OCTOR) was used to manually delineate the inner and outer boundaries of the EZ
layer and the choroid. The sub fo.. View More»
DOI:
10.35248/2155-9570.21.s13.001