Immunotherapy: Open Access
Open Access
ISSN: 2471-9552
ISSN: 2471-9552
Department of Gastroenterology, Tongren Hospital of Wuhan University, Wuhan, 430060, China
Research Article
AEBP1 Predicts Clinical Prognosis and is Associated with Immunocyte Infiltration in Gastric Cancer
Author(s): Xiaodong Huang*, Xia Tian*, Xiaoli Chen, Yiyuan Wan, Mengge Chen, Jiaxi Liu, Junsheng Deng and Ting Zhan
Adipocyte enhancer-binding protein 1 (AEBP1) is differentially expressed in various tumors. However, the relationship between AEBP1 and immune cell infiltration in Gastric Cancer (GC) remains unclear. Epigenetic regulation and transcriptional expression of AEBP1 in various clinicopathological parameters were detected using UALCAN database. Associations between infiltrating immune cells and their corresponding gene marker panels and AEBP1 expression were examined using the TIMER database. Kaplan-meier survival curve was used to evaluate the relationship between AEBP1 expression and overall survival and progression-free survival. AEBP1 expression in GC tissues was higher than that in normal tissues (P<0.05). The high expression of AEBP1 and the high methylation level of AEBP1 were associated with the high incidence and TNM stage of malignant tumor. In addition, the expression of AEBP.. View More»
DOI:
10.35248/2471-9552.22.08.194