Immunotherapy: Open Access
Open Access

Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Peking Union Medica, Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases, Beijing 100021, China

Publications

• Research Article   
  The Diversity and Heterogeneity of TCR and BCR in Pan-Cancer
  Author(s): Yu-Bao Chen*, Bo Li, Wen-Xiang Hu*, Li-Da Xu*, Hui-Xue Tang, Jing Zhang and Jin-Dan Guo
  
  Introduction: With the development of the sequencing technology, RNA-seq is becoming more and more popular. The method of using RNA-seq technology to analyze the immune repertoire has the advantages of low sample demand, simple operation, and comprehensive information. Methods: RNA-sequencing data were downloaded from SRA in NCBI, including 79 pairs of cancerous and adjacent noncancerous tissues samples of four representative cancer types, based on the literature, CutAdapt software was adopted to remove adapters, barcode bases, and low-quality bases. MiXCR software package was employed to extract immune repertoire receptor sequences. Results: The RNA-seq data from public database were used to analyze and compare the TCR and BCR sequences of cancer and normal tissues in four types of cancers, including colon adenoca.. View More»
  DOI: https://doie.org/10.0313/IMT.2023640551

  Abstract HTML PDF