Immunotherapy: Open Access
Open Access

Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

Publications

• Research Article   
  A Perspective of Matrix Metalloproteases (MMP) Gene Expression Profile Revealed by Pan-cancer Transcriptome and Single Cell Data
  Author(s): Jinxiang Tan*, Yidan Gao, Zhao Li, Yuanyuan Wang and Linbang Wang
  
  Background: MMPs are a group of family genes that related to cancer progression, up regulation of most of the MMP genes in cancers are reported to be associated with promotion of invasion, angiogenesis, and immune surveillance avoidance. However, expression patterns of all MMPs in transcriptome level and single-cell level in a pan-cancer perspective have not been investigated. Methods: Both the Cancer Genome Atlas (TCGA) transcriptome and single-cell sequencing pan-cancer data from GEO (Gene Expression Omnibus) were applied. The MMP-based diagnostic model was constructed by LASSO regression analysis. Tumors were classified into MMP score-high and low groups by ssGSEA. Single-cell data was analysisd by Serat package. The expression characters of MMPs were validated by qRT-PCR. Results: MMP1, MM.. View More»
  DOI: 10.35248/2471-9552.22.8.199

  Abstract HTML PDF