ISSN: 2329-6917
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Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
Dr. Joanna Góra-Tybor is the Assistant Professor in the Department of Haematology, Medical University, Bia?ystok, Poland. Currently, Dr. Joanna Góra-Tybor is the author/reviewer in several international journals. He published more than 60 articles in journals and the articles are informative and got good citations.
Research Article
Primary and Secondary Central Nervous System Involvement in Acute Myeloid Leukemia
Author(s): ElÃ?¼bieta Patkowska*, Andrzej Szczepaniak, Marta Barańska, Maciej Kaźmierczak, Monika Paluszewska, Wiesław Wiktor Jędrzejczak, Renata Guzicka-Kazimierczak, Wanda Knopińska-Posłuszny, Olga Grzybowska-Izydorczyk, Agnieszka Pluta, Jarosław Piszcz, Izabela Dereń-Wagemann, Ewa Lech-Marańda and Joanna Góra-Tybor
Introduction: Central Nervous System involvement (CNSi) in patients with Acute Myeloid Leukemia (AML) rarely occurs. It is not well characterized clinically and lacks standardized treatments.
Patients and methods: A retrospective analysis of 77 consecutive AML patients with primary and secondary CNSi during 2004-2016 was performed in eight Polish haematological centres.
Results: 77 patients (38 with primary CNSi-AML) were included. Median age was 44 years in both groups. Elevated lactate dehydrogenase activity was found in the majority of subjects. Patients in primary CNSi-AML group more often had myelomonocytic and monoblastic AML subtypes (68.4%) compared to secondary CNSi AML (43.5%) (p=0.039). There were no differences between both groups in the number of leukocytes or the proportion of blast cel.. View More»
DOI:
10.35248/2329-6917.19.7.257