ISSN: 2471-9552
+44 1223 790975
Department of Bionanoengineering, Hanyang University, Gyeonggi-do, 15588, Korea
Short Communication
A Brief Note on Cytokine-Induced Killer Cells
Author(s): Jong Wook*
Cytokine-Induced killer (CIK) cells are raising growing interest in cellular antitumor therapy, as they can be easily
expanded with a straightforward and inexpensive protocol, and are safe requiring only GMP-grade cytokines to obtain
very high amounts of cytotoxic cells. CIK cells do not need antigen-specific stimuli to be activated and proliferate, as
they recognize and destroy tumor cells in an HLA-independent fashion through the engagement of NKG2D. In
several preclinical studies and clinical trials, CIK cells showed reduced allo reactivity compared to conventional T
cells, even when challenged across HLA-barriers... View More»
DOI:
10.35248/2471-9552.21.s1.003