Immunotherapy: Open Access
Open Access

Department of Bionanoengineering, Hanyang University, Gyeonggi-do, 15588, Korea

Biography

Jong Wook Hong is currently a professor of Bionano Technology and Bionano Engineering, Hanyang University, Korea. Hong has published research articles in various scientific journals including Science and Nature Biotechnology and holds more than ten US patents granted or pending. Hong’s research interests cover convergence microsystems for biotechnology, pharmaceutical sciences and future medicine.

Publications

• Research Article   
  Neuroprotective Effect of Glial Cell-Derived Exosomes on Neurons
  Author(s): Sujin Hyung, Ju Young Kim, Chan Jong Yu, Hyun Suk Jung and Jong Wook Hong*
  
  Recent research has revealed that exosomes affect several aspects of organism physiology and development, as well as disease processes, through intracellular communication. However, the biological roles of exosomes in exosomesecreting cells have remained largely unexplored. In this study, we demonstrate that Schwann cell (SC)-derived exosomes (EXOSC) promote cell survival among motor neurons (MNs), with MN viability exceeding 80% at days in vitro (DIV) 14. Prevention of MN cell death by EXOSC was achieved by blocking the caspase-3 cell death pathway, which was confirmed by comparing the number of activated-caspase3+ cells according to the presence versus absence of EXOSC. The attenuation of exosome secretion from SCs by treatment with GW4869 resulted in increased MN cell death, regardless of SC viability. Together, these findings enhance our understand.. View More»
  DOI: 10.35248/2471-9552.19.5.156

  Abstract HTML PDF