ISSN: 2472-4971
Division of Hematology and Oncology, Department of Internal Medicine, Nashville, Tennessee, USA
Jordan Berlin, M.D, is a medical oncologist who specializes in gastrointestinal cancers and investigational drug development (Phase I). In his roles as the Associate Director for Clinical Research and Director of Phase I Research at the Vanderbilt-Ingram Cancer Center, Dr. Berlin serves to coordinate clinical and translational efforts across the cancer center from the research programs to the phase I program as well as from within the VICC research programs. He is responsible for advancing preclinical data and investigational drugs to investigator-initiated trials and clinical evaluation.
Research
Peritoneal Carcinomatosis in Well-Differentiated Small-Intestinal Neuroendocrine Tumors with Mesenteric Tumor Deposits
Author(s): Satya Das*, Chanjuan Shi, Tatsuki Koyama, Yi Huang, Raul Gonzalez, Kamran Idrees, Christina Edwards Bailey and Jordan Berlin
Objective: Well-differentiated small-intestinal neuroendocrine tumors (SI-NETs) tend to be biologically indolent.Despite this tendency, they have a predilection for metastasis. Peritoneal involvement is quite common as isunfortunately peritoneal carcinomatosis (PC). PC is a dreaded metastatic complication due to the significant morbidity it creates for patients as well as well as increasing their mortality risk. The risk factors for PC development in SI-NETs remain understudied; however, one such factor may be the presence of mesenteric tumor deposits (MTDs).
Methods: We performed a retrospective analysis on 208 well-differentiated SI-NET patient samples, the majority with mesenteric masses, from the pathology archives of Vanderbilt University Medical Center. We sought to explore whether MTD presence was associated with PC, what other patien.. View More»