Journal of Sleep Disorders & Therapy
Open Access
ISSN: 2167-0277
+44 1478 350008
ISSN: 2167-0277
+44 1478 350008
Medical Director, Division of Pulmonary, Critical Care, and Sleep Medicine, SLUCare Sleep Disorders Center, Saint Louis University School of Medicine, USA
Dr. Joseph Espiritu directs the SLUCare Sleep Disorders Center, where he conducts sleep studies for evaluation and management of sleep disorders using methods such as polysomnograms, home sleep apnea tests, multiple sleep latency tests, and maintenance of wakefulness tests. Beyond sleep medicine, Dr. Espiritu treats patients with obstructive lung diseases, such as COPD and asthma.
Review Article
Health Consequences of Obstructive Sleep Apnea
Author(s): Joseph Roland D Espiritu*
Obstructive sleep apnea (OSA), in addition to causing hypersomnolence and fatigue, adversely affects virtually every organ system, resulting in adverse neurologic, cardiovascular, respiratory, endocrine, gastrointestinal, obstetric, perinatal, perioperative, accident-related, and mortality-related health outcomes. Nocturnal respiratory dysfunction (i.e., hypoxemia-reoxygenation and hypercapnia), poor sleep quality (i.e., increased arousals, poor sleep efficiency, and altered sleep architecture), and intrathoracic pressure variations, in addition to shared comorbid risk factors, result in oxidative stress, inflammation, sympathetic activation, endothelial dysfunction, neurohormonal changes, thrombophilia, and hemodynamic changes, which are the pathophysiologic mechanisms for these adverse clinical outcomes... View More»
DOI:
10.35248/2167-0277.19.8.307.