Immunotherapy: Open Access
Open Access

Department of Bionanotechnology, Graduate School, Hanyang University, Seoul, 04763, Korea

Biography

Postdoctoral Research Fellow at Princeton University, Haw Yang Group
yanglab.princeton.edu/ Joint Appointment with the National Institutes of Natural Sciences (NINS) in Japan as the Specially Appointed Research Employee, Ryota Iino Laboratory
groups.ims.ac.jp/organization/iino_g

Publications

• Research Article   
  Neuroprotective Effect of Glial Cell-Derived Exosomes on Neurons
  Author(s): Sujin Hyung, Ju Young Kim, Chan Jong Yu, Hyun Suk Jung and Jong Wook Hong*
  
  Recent research has revealed that exosomes affect several aspects of organism physiology and development, as well as disease processes, through intracellular communication. However, the biological roles of exosomes in exosomesecreting cells have remained largely unexplored. In this study, we demonstrate that Schwann cell (SC)-derived exosomes (EXOSC) promote cell survival among motor neurons (MNs), with MN viability exceeding 80% at days in vitro (DIV) 14. Prevention of MN cell death by EXOSC was achieved by blocking the caspase-3 cell death pathway, which was confirmed by comparing the number of activated-caspase3+ cells according to the presence versus absence of EXOSC. The attenuation of exosome secretion from SCs by treatment with GW4869 resulted in increased MN cell death, regardless of SC viability. Together, these findings enhance our understand.. View More»
  DOI: 10.35248/2471-9552.19.5.156

  Abstract HTML PDF