Journal of Clinical Toxicology
Open Access

Division of Otolaryngology, St. Paul's Sinus Centre, University of British Columbia, Vancouver, Canada

Biography

Juan Carlos Hernaiz-Leonardo Otolaryngology and H&N Surgery. Ph.D. Student at the University of British Columbia, Vancouver, Canada. He took part in writing the paper entitled " In vitro Inactivation of SARS-Cov-2 by Povidone-Iodine In situ Gel Forming Solution"

Publications

• Research Article   
  In vitro Inactivation of SARS-Cov-2 by Povidone-Iodine In situ Gel Forming Solution
  Author(s): Bo Liang*, Xudong Yuan, Gang Wei, Wei Wang, Ming Zhang, Haizhou Peng, Juan C. Hernaiz-Leonardo, Amin Javer, Michelle Mendenhall, Justin Julander, Sammi Huang, Hany Michail, Yong Lu, Qi Zhu and John Baldwin
  
  Background: Povidone Iodine (PVP-I) nasal solutions are effective against the SARS-CoV-2 virus, but are cleared rapidly from the nasal cavity, limiting its use. PVP-I gel forming solutions can circumvent this problem due to their higher viscosity and prolonged clearing time. Objective: Characterize the in vitro virucidal activity of long-acting PVP-I compositions developed using an in situ gel forming technology against the SARS-CoV-2 virus and test its safety using a rat model. Methods: We tested different dilutions of the PVP-I gel forming solution– full concentration, 90%, 50%, 28% and 9% of the original formulation concentration – at varying exposure times to assess virucidal activity against SARSCoV- 2 in VERO76 cells infected. Virucidal activity was recorded as the reduction of v.. View More»
  DOI: 10.35248/2161-0495.21.s18.002

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