ISSN: 2475-7586
Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, USA
Julie G. Pilitsis is Currently working at Department of Neurosurgery, Albany Medical Center, Albany, NY, USA. Professor of Neurosurgery, Professor Albany Medical College, Wayne State University, Higher Education, Rush Medical College of Rush University Medical Center Higher Education. His Current Research Interest Includes Validation of a Novel Noxious Pressure Device for Use in fMRI Pain Studies.
Research
Validation of a Novel Noxious Pressure Device for Use in fMRI Pain Studies
Author(s): Marisa DiMarzio, Michael Spinrad, Maria Hancu, Ellinor Grinde, Jamie Chang, Julia Slyer, Michael Gillogly, Julia Prusik, Julie G. Pilitsis*, Eric Fiveland and Ileana Hancu
Background: Most fMRI studies on pain perception utilized thermal stimuli due to the lack of a non-metallic reliable, reproducible mechanical stimulus. We explored 2 potential MR compatible mechanical devices and validated one that induced changes on fMRI.
Purpose: To validate a noxious mechanical stimulus MR compatible device in a healthy cohort and a chronic pain cohort. Further to ensure this device caused changes on fMRI compared to a pressure device.
Methods: Two-healthy controls underwent fMRI scans in the presence/absence of mechanical noxious stimuli using different devices. A paradigm for administering the stimuli with the most robust responses on fMRI was developed. Reproducibility of the device was confirmed in 10 chronic pain patients and age/gender-matched healthy controls. Comparisons of patient demog.. View More»
DOI:
10.35248/2475-7586.19.4.138