Immunotherapy: Open Access
Open Access
ISSN: 2471-9552
ISSN: 2471-9552
Department of Gastroenterology, The First Affiliated Hospital of Xinxiang Medical College, Street Health 88, Xin Xiang, 453100, China
Research Article
A Novel CCR7- Related Immune Prognostic Signature for Liver Hepatocellular Carcinoma (LIHC) Based on Immunogenomic Profiling
Author(s): Xinhui Wang*, Baolin Zhou, Lei Qin, Jun Kuai, Fang Yang, Lu Yang, Lanfang Zhang, Peisheng Sun and Guangpeng Li
Object: Explore the specific function of CCR7 in immune mechanism of LIHC, and constructed CCR7-related Immune Prognostic Signature (IPS) for LIHC patients.
Methods: The RNA-seq data of LIHC was downloaded from TCGA dataset and the samples were divided into CCR7_H and CCR7_L group. Then, ssGSEA analysis, immune microenvironment analysis, expression level analysis of HLA genes and check point genes were conducted. The Differential Expression Immune Genes (DEIGs) were conducted and LASSO Cox was applied to construct CCR7-related IPS. A novel nomogram was constructed to predict survival rate of LIHC patients.
Results: The Immune score, Stromal score and ESTAMATE score are higher in CCR_H group, while tumor purity higher in CCR_L group. In CCR7_H g.. View More»
DOI:
10.35248/2471-9552.22.8.191