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Department of Chemistry, Sri Krishnadevaraya University, India
Dr. K Hussain Reddy is a Senior Professor in Sri Krishnadevaraya University, Department of chemistry. He has done Ph.D. in chemistry (1984) Sri Krishnadevaraya University, Anantapur. He has done Post Doctoral Research in the University of California San Diego for a period of one year during 1989-90 under HRD, Govt. of India Fellowship. He has 37 Years of research experience in the field of Inorganic Chemistry and Pharmaceutical Chemistry. He’s Area of Expertise both in Teaching and Research: Bioinorganic Chemistry, Supramolecular Chemistry, Electro Chemistry, Electro Chemistry and Analytical Chemistry.
Research Article
DNA Binding and Antimicrobial Studies on Bivalent Transition Metal Complexes with 2-Acetylpyridine Isonicotinoylhydrazone
Author(s): K Hussain Reddy* and YB Nagaman
Bivalent transition metal [Co(II), Ni(II), Cu(II) and Zn(II)] complexes with 2-acetylpyridine isonicotinoyl hydrazone(APINH, LH) have been prepared and analyzed based on mass spectra, molar conductivity, FT-IR and UVVis spectral data. The ML2complexes are found to be non-electrolytes. From FT-IR data it is evident that the APINH acts as uni-negative tridentate ligand. Electronic spectral data confers octahedral structure for the complexes. The copper complex is also studied using ESR spectroscopy. The Spin Hamiltonian, orbital reduction and bonding parameters are determined for the complex. DNA binding properties of the complexes uncovered by using UVVisible spectrophotometry. Of all the compounds, the nickel complex binds more strongly than either. The metal complexes are screened for their antibacterial activity against pathogenic bacterial strains viz. Gram–ve bacteria (Esc.. View More»
DOI:
10.35248/jcma.21.5.106