Fungal Genomics & Biology
Open Access
ISSN: 2165-8056
ISSN: 2165-8056
Yongchuan Hospital, Chongqing Medical University, Xuanhua Road, Chongqing, People's Republic of China
Research Article
A Systematic Review and Meta-Analysis of Diagnostic Accuracy of Serum (1-3)-Beta-D-glucan for Pneumocystis
jirovecii Pneumonia Using the Fungitell Assay: Focus on Cutoff Levels
Author(s): W. Long, K. Xiao and Y. Yuan*
Purpose: We conducted a meta-analysis to evaluate the diagnostic performance of various levels of serum (1-3)-Beta- D-glucan (BDG) for Pneumocystis jirovecii (PJ) infection using Fungitell assay.
Methods: EMBASE, MEDLINE, and the reference lists of relevant studies were identified up to March 12, 2021, with no language restrictions. Meta-analysis was performed using random-effects models for bivariate analysis. Subgroup analyses were implemented in HIV-positive Pneumocystis jirovecii pneumonia (PJP), HIV-negative PJP, and PJP versus colonized patients.
Results: Nineteen individual studies that included a total of 2,310 participants met our inclusion criteria. The overall sensitivity, specificity, positive likelihood ratio(LR+) and negative likelihood ratio (LR-),and 95% confidence interval CI of s.. View More»
DOI:
10.35841/2165-8056.22.12.193