Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Department of Cardiovascular Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Research Article
Inhibition of IL-1? Secretion and Mitochondria Respiration by Arsenite which acts on Myocardial Ischemia-Reperfusion Injury
Author(s): Min Li, Yingwu Mei, Jingeng Liu, Kaikai Fan, Xinyue Gu, Xu Zhang, Jitian Xu, Yuebai Li, Haifeng Zhang, Ge Jin and Yang Mi*
Arsenite (NaAsO2) is a potent toxin that significantly contributes to human pathogenesis. Chronic exposure to
arsenite results in various diseases. The physiologically important biological target(s) of arsenite exposure is largely
unknown. Here we found that transient sodium arsenite treatment (1) blocks nigericin or Rotenone induced IL-
1β secretion; (2) inhibits mitochondrial respiration with complex I-linked substrate; (3) induces Heme oxygenase-1
(HO-1) in myocardial tissue, (4) attenuates the myocardial ischemia-reperfusion injury in an in vivo model of rats.
The causal relationship among these activities needs further investigation... View More»
DOI:
10.35248/2161-0495.21.11.487