Hair Therapy & Transplantation
Open Access

Department of Biotechnology, Yonsei University, Seoul, South Korea

Publications

• Short Communication   
  Recent Updates on Development of Wnt/?-catenin Pathway Activators for Alopecia Treatment
  Author(s): Soung-Hoon Lee and Kang-Yell Choi*
  
  Wnt/β-catenin signaling pathway plays central roles in regulating homeostasis and regeneration in the hair follicular stem cell niche. Thus, this pathway should be used as a therapeutic target for alopecia, but there are still limitations. Valproic Acid (VPA), an activator of canonical Wnt signaling, induced hair re-growth and regeneration in mice, but had limited clinical efficacy. This might be due to the induction of CXXC-type zinc finger protein 5 (CXXC5), a negative regulatory factor of this regenerative pathway and hair follicle regeneration, by VPA. To overcome the limitations caused by this negative regulatory factor, a competing peptide and small molecular compounds that inhibit CXXC5 function were developed, and they were found to restore the canonical Wnt pathway and hair follicle regeneration suppressed by CXXC5 in bald.. View More»
  DOI: 10.35248/2167-0951.23.13.212

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