Journal of Clinical and Experimental Ophthalmology
Open Access

Department of Ophthalmology, Laboratory of Experimental Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Prigkipos Christoforou 4, 62100, Serres, Greece

Publications

• Research Article   
  Inner Retinal Layers as Biomarkers of Disease in Patients with Mild Cognitive Impairment
  Author(s): Demirtzoglou Iordanis*, Tsolaki Magda, Gougoulias Kyriakos, Oikonomidis Panagiotis and Karampatakis Vasileios
  
  Purpose: To investigate whether inner retinal thickness can be used as a reliable biomarker in patients with mild cognitive impairment (MCI) for early diagnosis and correlate these changes with cognitive decline. Material and methods: Using spectral domain optical coherence tomography (SD-OCT) in MCI and control subjects we assess peripapillary Retinal Nerve Fiber Layer (RNFL) thickness, macular thickness and volume and macular Ganglion Cell Complex (mGCC was defined as the combination of retinal fiber, ganglion cell and inner plexiform layers) thickness, Ganglion Cell Complex Global Volume Loss (GCC GVL%) and Ganglion Cell Complex Focal Volume Loss (GCC FVL%). We assessed cognitive function using Mini Mental State Examination (MMSE) score. A database was created with the use of the Statistical Program for Social Sciences (SP.. View More»
  

  Abstract PDF