Journal of Clinical Chemistry and Laboratory Medicine
Open Access

Department of Medicine, University of Arizona Cancer Center, Tucson, Arizona, USA

Publications

• Research   
  Gut Microbiota and Central Nervous System: A Bidirectional Two-Sample Mendelian Randomized Analysis
  Author(s): Karl Krupp* and Qingfeng Wang
  
  Background: Previous studies have shown that alterations in the gut microbiota are associated with the progression of Central Nervous System (CNS) disorders. Whether this connection reflects a causal relationship still unclear. We aimed to reveal a causal relationship between the gut microbiota and CNS diseases such as Anoxic Brain Injury (ABI) and Bacterial Meningitis (BM). Methods: A two-sample bi-directional Mendelian Randomization (MR) analysis was performed by using genetic variants from genome-wide association studies as instruments variables for gut microbiota, ABI and BM. This study used inverse variance weighted, weighted median, MR-Egger and weighted mode methods to evaluate the causal relationship among gut microbiota, ABI and BM. Sensitivity analyses including horizontal pleiotropy analysis, Cochran's Q test, and leave-one-ou.. View More»
  DOI: 10.35248/2736-6588.23.6.277

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