Journal of Clinical Toxicology
Open Access

BioArge Laboratories, Yıldız Technical University Technocity, İkitelli, Istanbul 34490, Turkey

Publications

• Research Article   
  In Vitro Study on Tribologically Micronized Zeolite as A Natural Cell Protecting Chelator of Lead (II) Acetate
  Author(s): Tugba Sagir*, Mehmet Kenar, Gokhan Ozokan and Kerim Bilginer
  
  In order to determine whether clinoptilolite, a naturally occurring zeolite, had any toxic effect on keratinocyte cells when combined with lead (II) acetate, real time cell analysis and MTS assays were performed. Herein, Micronized Zeolite (MZ) was obtained by tribomechanical micronization of natural clinoptilolite. The effect of lead (II) acetate (Pb (CH3COO) 2.3H2O) adsorption of clinoptilolite at different durations (30 minutes, 1 hour, 2 hours, 4 hours, 8 hours) was investigated. When 5% clinoptilolite was applied to the lead (II) acetate solution, the adsorption capacity was 55.15% in 30 minutes, 58.09% in 1 hour, 71.62% in 2 hours, 82.66% in 4 hours, 87% in 8 hours. These results were in parallel with cell culture studies which showed when lead is treated with tribologically micronized zeolite (Clinoptilolite) it increases the cell viability... View More»
  DOI: 10.35248/2161-0495.21.11.484

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