Journal of Clinical Toxicology
Open Access

Department of Biology, Kotebe Metropolitan University, Addis Ababa, Ethiopia

Biography

Dr. Kero Jemal ia currently working in Kotebe Metropolitan University, Addis Ababa, Ethiopia in the department of Biology, His recent publications are Molecular Docking Studies of Phytochemicals of Allophylus Serratus against  Cyclooxygenase-2 Enzyme

Publications

• Case Report   
  Molecular Docking Studies of Phytochemicals of Allophylus Serratus against Cyclooxygenase-2 Enzyme
  Author(s): Kero Jemal*
  
  Background: Allophylus serratus is a medicinal plant used traditionally as anti-inflammatory agent. The main objectives of this study are to identify phytochemical compounds that have anti-inflammatory properties from the leaf extracts of Allophylus serratus and to search for cyclooxygenase-2 (COX-2) enzyme inhibitors through molecular docking. Result: From the GC-MS analysis of leaf extracts of Allophylus serratus, ten of the phytochemical compounds which satisfy were analyzed for their drug likeliness based on Lipinski’s rule of five and inhibitor property against the Cyclooxygenase (COX-2) enzyme, a protein responsible for inflammation. These phytochemical compounds were subjected to docking experiments using Auto Dock Vina. The results from molecular docking study revealed that 1H-Benzocycloheptene, 2,4a,.. View More»
  DOI: 10.35248/2161-0495.21.s18.005

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