Advances in Medical Ethics
Open Access

Department of Pharmaceutical Technology, American University of Afghanistan, Near Palace of Darual Aman, Darulaman Rd, Kabul, Afghanistan

Publications

• Perspective   
  In vivo Micro RNA-Mediated Suppresion of Genes in Zebrafish
  Author(s): Khaled Sayeed*
  
  Due to the abundance of orthologous genes that encode proteins that are comparable to those found in humans, the zebrafish (Danio rerio) has emerged as a promising model for the study of human disease. The zebrafish genome can only be modified with a small set of tools, and many of the methods now in use are either successful in the early stages of development (such as morpholino-based antisense technology) or are phenotypically driven without providing specific gene knockdown (such as chemical mutagenesis). The use of RNA interference has been controversial because off-target effects can make it challenging to interpret phenotypic results. This problem has been han.. View More»
  DOI: 10.35248/2385-5495.22.8.014

  Abstract HTML PDF