Journal of Medical & Surgical Pathology
Open Access
ISSN: 2472-4971
ISSN: 2472-4971
Department of Anatomical Pathology, Singapore General Hospital, Singapore
Review Article
Detection of Usual and Unusual IDH Mutations in Cerebrospinal Fluid: A Case Illustration and Discussion around the Potential of Liquid Biopsy in the Practice of Surgical Neuropathology
Author(s): Ming Lee*, Gek San Tan, Chee Kian Tham and Kiat-Hon Tony Lim
Isocitrate dehydrogenase (IDH) mutations are a common event in secondary glioblastoma multiforme
and lower-grade adult infiltrative astrocytomas and independently confer a better prognosis. These
are highly conserved mutations during glioma progression and thus also a useful diagnostic marker
amenable to modern molecular sequencing methods. These mutations can even be detected in sites
distant from the primary tumour. We use an illustrative case of a patient with radiologically suspected
recurrent astrocytoma and negative histology, but positive IDH-mutated tumour DNA detected within
CSF. Our results demonstrated the usefulness of liquid biopsy for recurrent glioma within the context of
equivocal or negative histopathological results, whilst also showing the ability to detect a de-novo IDH-2
mutation not present in the previous resection. Building on this &lsq.. View More»
DOI:
10.35248/2472-4971.5.4.185