Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Department of Immunology, Dr Ram Manohar Lohia Hospital, Baba Kharak Singh Marg, New Delhi, India
Research Article
iTreg Mediated TGF-β1 Therapy Improves Functional Engraftment of Cell Therapy in rd1 Retinitis Pigmentosa Mouse Model
Author(s): K Varsha Mohan, Alaknanda Mishra, Prakriti Sinha, Abaranjitha Muniyasamy, Perumal Nagarajan, Kiran Chaudhary and Pramod Upadhyay*
Purpose: Retinitis Pigmentosa (RP) is a progressive and hereditary disease that primarily affects the retina, leading to partial or complete vision loss. In addition to the direct impact on vision, the degeneration of the retina in RP also leads to inflammation in the eye, which can further damage the retina and make it difficult to treat the condition with cell therapy. This inflammation led to oxidative stress and cell death, creating an unfavorable environment for the introduction of new cells via cell therapy.
Materials and methods: The potential of Transforming Growth Factor-Beta1 (TGF-β1) as an anti-inflammatory agent to treat ocular inflammation was investigated done by administering TGF-β1 intravitreally to the eyes of rd1 mice. However, due to the transient effect of TGF-β1 injection, the in vitro indu.. View More»
DOI:
10.35248/2155-9570.24.15.977