Pediatrics & Therapeutics
Open Access

Department of Pediatrics, Ehime University, Graduate School of Medicine, Toon, Ehime, Japan

Biography

Kozo Nagai works at Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan. Kozo Nagai has published more than 5 abstracts. Research interests are Pediatric Infectious Diseases, Neonatal Medicine, Reproductive Medicine, Endocrinology, Andrology, Pediatrics.

Publications

• Original Research Article   
  High Concentration of Vancomycin in Children with Central Diabetes Insipidus: A Retrospective Case Series
  Author(s): Fumihiro Ochi*, Hisamichi Tauchi, Hiroshi Kimura, Junpei Hamada, Mayo Ueda, Toshihiro Jogamoto, Kozo Nagai, Minenori Eguchi-Ishimae and Mariko Eguchi
  
  Although the high concentration of vancomycin (VCM) has the potential to cause acute kidney injury and ototoxicity, there were no studies focused on its pharmacokinetics in children with central diabetes insipidus (CDI). We, therefore, evaluated the pharmacokinetic indices of VCM in children with CDI diagnosed and treated at Ehime University Hospital between January 2008 and December 2019. Five patients with CDI administered VCM, were retrospectively reviewed. VCM median initial dose, trough value, clearance (CL) and half-life (t1/2) were 42.0 mg/kg/day (range, 18.8 mg/kg/day-60.0 mg/kg/day), 34.5 mg/L (range, 12.5 mg/L-182 mg/L), 6.54 mL/min (range, 1.57-47.1 mL/min), and 7.11 hr (range, 3.35 hr -38.5 hr), respectively. VCM trough values were high in cases of untreated or inadequately treated CDI. Our results suggest that the decrease in CL and the increase in the volume of distribut.. View More»
  

  Abstract PDF