Endocrinology & Metabolic Syndrome
Open Access

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Publications

• Case Report   
  Tumour Induced Osteomalacia-Unique Presentation
  Author(s): Krishna Kumar Chinnadurai* and Akshaya Jayachandran
  
  Tumour-induced osteomalacia (TIO), also known as oncogenic osteomalacia is a rare paraneoplastic syndrome characterized by severe persistent hypophosphatemia. It occurs due to excess production of phosphatonins, which clinically manifests as severe hypophosphatemia. In our case, a 37-year-old woman presenting with multiple joint pains for last 9 years, progressive weakness of bilateral lower limbs for the last 1 year and past history of long bone fractures was diagnosed with tumor-induced osteomalacia (TIO) although she had normal FGF23 levels. TIO was caused by phosphaturic mesenchymal tumour in right tibia. After surgical resection of the tumour, her symptoms resolved. This is a unique case in that the patient had a normal systemic FGF23 level even with severe manifestations of TIO and also patient had raised parathyroid hormone levels which create a confusion of parathyroid related.. View More»
  DOI: 10.35248/2161-1017.20.9.317

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