Journal of Clinical Toxicology
Open Access

Department of Toxicology, Teaching Hospital Peradeniya, Kandy, Sri Lanka

Publications

• Case Report   
  Severe Toxic Myocarditis Following Sodium Valproate Poisoning: A Management Hurdle
  Author(s): Aruna Shantha DW*, Kulasinghe A and Hettiarachchi NM
  
  Sodium valproate is a commonly reported medication with self-inflicted overdose causing morbidity and mortality with severe toxicity. Myocarditis is not a commonly reported complication in valproate poisoning. There is no consensus guideline for the management up to date. We are reporting a case of severe myocarditis with refractory hypotension which was successfully treated with High-dose Insulin Euglycemic Therapy (HIET). We highlight the importance of anticipating toxic myocarditis as a complication of valproic acid poisoning and the possibility of restoration of “metabolic hunger” by HIET which could have been caused by the depletion of myocytic L-carnitine activity... View More»
  DOI: 10.35248/2161-0495.24.14.568

  Abstract HTML PDF