Enzyme Engineering
Open Access

Department of Medical Studies, Government Medical College and Hospital, Jalgaon, Maharashtra, India

Publications

• Short Communication   
  Repurposing Inhibitors for SARS-CoV2 Main Protease
  Author(s): Kumar Sharp*
  
  SARS-CoV2 main protease is important for viral replication and one of the most potential targets for drug development in this current pandemic. Drug repurposing is a promising field to provide potential short-term acceptable therapy for management of coronavirus till a specific anti-viral for coronavirus is developed. In-silico drug repurposing screening is the current fastest way to repurpose drugs by targeting active sites in fraction of seconds. In this study, SARS-CoV2 main protease is being targeted by 1050 FDA-approved drugs to inhibit its activity thereby interfering with viral replication. Chemotherapeutic drugs and anti-retroviral drugs have shown potential binding as inhibitor. In-vitro and clinical trials required to establish final fact... View More»
  DOI: 10.35841/2165-8056.22.11.189

  Abstract HTML PDF