Journal of Clinical Trials
Open Access
ISSN: 2167-0870
ISSN: 2167-0870
Institute of Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China
Research
Mechanism of Ozone Alleviation of Malignant Ascites in Hepatocellular Carcinoma through Inhibition of NETS
Author(s): Feng Han, Jiayou Guo, Mingchen Mu, Ka Bian, Zhenting Cui, Qiong Duan, Jianxin Ma*, Lai Jin*, Wentao Liu* and Fanghong Chen*
Malignant ascites in hepatocellular carcinoma is usually a sign of advanced disease and poor prognosis and is also
thought to be associated with chronic inflammation mediated by Neutrophil Extracellular Trap-networks (NETs).
Whereas ozone, a strong oxidant, has significant antibacterial and anti-inflammatory effects, its effectiveness in
treating malignant liver ascites is unclear. cOzone showed significant anti-peritoneal fluid production properties in
H22 tumor-bearing mice, and ozone reduced peritoneal fluid production by activating AMPK and up-regulating
SR-A phagocytosis Damage-Associated Molecular Patterns (DAMPs) to reduce the production of NETs. This
suggests that ozone could be used as a new drug for the treatment of malignant ascites in hepatocellular carcinoma... View More»
DOI:
10.35248/2167-0870.23.13.529